International Journal of Health Policy and Management

International Journal of Health Policy and Management

Gastric Cancer: Bibliometric Analysis of Epidemiological, Geographical and Socio-Economic Parameters of the Global Research Landscape

Document Type : Original Article

Authors
Doris Klingelhöfer
Markus Braun
Norman Schöffel
Dörthe Brüggmann
David A. Groneberg
Institute of Occupational, Social and Environmental Medicine, Goethe University, Frankfurt, Germany
10.34172/ijhpm.2020.29
Abstract
Background
Although the incidence and mortality of gastric cancer (GC) decreased in the last years, some countries remain highly affected. Especially in high-income economies the cases of cardia types are steadily increasing. Currently, GC is ranked third as cause for cancer death worldwide, whereby two-thirds of deaths still occur in lowincome countries. But the global numbers are changing, and new regional challenges must be addressed.

 
Methods
Therefore, this disease has been chosen for in-depth bibliometric analyses that combines the evaluation of publication meta-data with density equalizing visualization techniques. This study focuses on the chronological and geographical characteristics of GC research worldwide. Epidemiological and socio-economic parameters were analyzed and the influence of political framework conditions was examined. In addition, international collaborations and research priorities were evaluated.

 
Results
In the last years, the publication numbers are rising more extensively in comparison to other cancer types. Albeit the usual leading positions, the United States is not the most publishing country on GC. It occupies the third position. Instead, China and Japan are the most publishing countries and together with South Korea also the key players as well as the most affected countries. These countries’ governments are also the main donors for GC-research. The number of articles and the expenditures for research and development (R&D) as well as the incidence rate are correlated. Despite the scarce contribution of low-economic countries to the publication output, international collaborations lead to a modest output in those regions.

 
Conclusion
This study pools background information for scientists, practitioners, funders and decision-makers by providing information on the development and priorities of GC research. Adaptive international approaches and partnerships are crucial to meet future changing epidemiological features worldwide.

Highlights

Supplementary File 1 (Download)

Keywords
Stomach Cancer
Cancer Epidemiology
Research Funding
Bibliometric Analysis
Socio-Economic Influences
  1. IARC. Cancer Today, Estimated age-standardized incidence rates (World) in 2018, worldwide, both sexes, all ages. https://rb.gy/9xlaf6. Accessed October 2019. Published 2018.
  2. Arnold M, Pandeya N, Byrnes G, et al. Global burden of cancer attributable to high body-mass index in 2012: a population-based study. Lancet Oncol. 2015;16(1):36-46. doi:10.1016/s1470-2045(14)71123-4
  3. Sitarz R, Skierucha M, Mielko J, Offerhaus GJA, Maciejewski R, Polkowski WP. Gastric cancer: epidemiology, prevention, classification, and treatment. Cancer Manag Res. 2018;10:239-248. doi:10.2147/cmar.s149619
  4. Stock M, Otto F. Gene deregulation in gastric cancer. Gene. 2005;360(1):1-19. doi:10.1016/j.gene.2005.06.026
  5. Uthman OA, Jadidi E, Moradi T. Socioeconomic position and incidence of gastric cancer: a systematic review and meta-analysis. J Epidemiol Community Health. 2013;67(10):854-860. doi:10.1136/jech-2012-201108
  6. Camargo MC, Anderson WF, King JB, et al. Divergent trends for gastric cancer incidence by anatomical subsite in US adults. Gut. 2011;60(12):1644-1649. doi:10.1136/gut.2010.236737
  7. Blaser MJ, Chen Y. A new gastric cancer among us. J Natl Cancer Inst. 2018;110(6):549-550. doi:10.1093/jnci/djx279
  8. Lagergren F, Xie SH, Mattsson F, Lagergren J. Updated incidence trends in cardia and non-cardia gastric adenocarcinoma in Sweden. Acta Oncol. 2018;57(9):1173-1178. doi:10.1080/0284186x.2018.1457797
  9. Groneberg-Kloft B, Fischer TC, Quarcoo D, Scutaru C. New quality and quantity indices in science (NewQIS): the study protocol of an international project. J Occup Med Toxicol. 2009;4:16. doi:10.1186/1745-6673-4-16
  10. Bruggmann D, Alafi A, Jaque J, et al. World-wide research architecture of vitamin D research: density-equalizing mapping studies and socio-economic analysis. Nutr J. 2018;17(1):3. doi:10.1186/s12937-018-0313-6
  11. Götting M, Schwarzer M, Gerber A, Klingelhöfer D, Groneberg DA. Pulmonary hypertension: scientometric analysis and density-equalizing mapping. PLoS One. 2017;12(1):e0169238. doi:10.1371/journal.pone.0169238
  12. Groneberg DA, Geier V, Klingelhöfer D, Gerber A, Kuch U, Kloft B. Snakebite envenoming–a combined density equalizing mapping and scientometric analysis of the publication history. PLoS Negl Trop Dis. 2016;10(11):e0005046. doi:10.1371/journal.pntd.0005046
  13. Falagas ME, Pitsouni EI, Malietzis GA, Pappas G. Comparison of PubMed, Scopus, web of science, and Google scholar: strengths and weaknesses. FASEB J. 2008;22(2):338-342. doi:10.1096/fj.07-9492LSF
  14. CIA. The World Factbook, 2017. https://www.cia.gov/library/publications/the-world-factbook/.  Accessed April 2017.
  15. WHO. Globocan 2018, Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2018. http://globocan.iarc.fr/Pages/summary_table_pop_sel.aspx.  Accessed July 2018.
  16. WHO. Globocan 2012, Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012. http://globocan.iarc.fr/Pages/summary_table_pop_sel.aspx. Accessed July 2018. Published 2012.
  17. OECD. OECD Data, Research and Development Statistics (RDS). http://www.oecd.org/innovation/inno/researchanddevelopmentstatisticsrds.htm.  Accessed May 2018. Published 2018.
  18. Klingelhöfer D, Zhu Y, Braun M, Brüggmann D, Schöffel N, Groneberg DA. A world map of esophagus cancer research: a critical accounting. J Transl Med. 2019;17(1):150. doi:10.1186/s12967-019-1902-7
  19. Gastner MT, Newman ME. Diffusion-based method for producing density-equalizing maps. Proc Natl Acad Sci U S A. 2004;101(20):7499-7504. doi:10.1073/pnas.0400280101
  20. van Eck NJ, Waltman L. VOSviewer: A Computer Program for Bibliometric Mapping. Proceedings of Issi 2009 - 12th International Conference of the International Society for Scientometrics and Informetrics. 2009;2:886-897.
  21. Van Noorden R. Global scientific output doubles every nine years. Nature News Blog.http://blogs.nature.com/news/2014/05/global-scientific-output-doubles-every-nine-years.html.  Accessed July 2018. Published 2014.
  22. Lauren P. The two histological main types of gastric carcinoma: diffuse and so‐called intestinal‐type carcinoma: an attempt at a histo‐clinical classification. Acta Pathol Microbiol Scand. 1965;64:31-49. doi:10.1111/apm.1965.64.1.31
  23. Parsonnet J, Friedman GD, Vandersteen DP, et al. Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med. 1991;325(16):1127-1131. doi:10.1056/nejm199110173251603
  24. Nomura A, Stemmermann GN, Chyou PH, Kato I, Perez-Perez GI, Blaser MJ. Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med. 1991;325(16):1132-1136. doi:10.1056/nejm199110173251604
  25. Blaser MJ, Perez-Perez GI, Kleanthous H, et al. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res. 1995;55(10):2111-2115.
  26. El-Omar EM, Carrington M, Chow WH, et al. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature. 2000;404(6776):398-402. doi:10.1038/35006081
  27. Correa P. Human gastric carcinogenesis: a multistep and multifactorial process--first American Cancer Society award lecture on cancer epidemiology and prevention. Cancer Res. 1992;52(24):6735-6740.
  28. Devesa SS, Blot WJ, Fraumeni JF Jr. Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer. 1998;83(10):2049-2053.
  29. Uemura N, Okamoto S, Yamamoto S, et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 2001;345(11):784-789. doi:10.1056/NEJMoa001999
  30. Macdonald JS, Smalley SR, Benedetti J, et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med. 2001;345(10):725-730. doi:10.1056/NEJMoa010187
  31. Bang YJ, Van Cutsem E, Feyereislova A, Investigators TT. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (TOGA): a phase 3, open-label, randomised controlled trial (vol 376, pg 687, 2010). Lancet. 2010;376(9749):1302-1302.
  32. Schöffel N, Brüggmann D, Klingelhöfer D, Bendels MHK, Groneberg DA. Crohn's disease: a critical approach to publication procedures and citation behavior of the global research network. J Clin Gastroenterol. 2018;52(3):246-254. doi:10.1097/mcg.0000000000000798
  33. Brüggmann D, Pulch K, Klingelhöfer D, Pearce CL, Groneberg DA. Ovarian cancer: density equalizing mapping of the global research architecture. Int J Health Geogr. 2017;16(1):3. doi:10.1186/s12942-016-0076-2
  34. The World Bank. World Bank Country and Lending Groups. https://datahelpdesk.worldbank.org/knowledgebase/articles/906519#High_income.  Accessed October 2019. Published 2019.
  35. Research and development expenditure - Country rankings, 2015. The Global Economy website.https://www.theglobaleconomy.com/rankings/Research_and_development/.  Accessed October 2018. Published 2015.
  36. Bosman FT, Carneiro F, Hruban RH, Theise ND. WHO Classification of Tumours of the Digestive System. Vol 3. 4th ed. WHO Press; 2010.
  37. Magri MH, Solari A. The SCI journal citation reports: a potential tool for studying journals? Scientometrics. 1996;35(1):93-117. doi:10.1007/BF02018235
  38. Warren JR, Marshall B. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet. 1983;1(8336):1273-1275.
  39. Forman D, Newell DG, Fullerton F, et al. Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. BMJ. 1991;302(6788):1302-1305. doi:10.1136/bmj.302.6788.1302
  40. Schistosomes, liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 7-14 June 1994. IARC Monogr Eval Carcinog Risks Hum. 1994;61:1-241.
  41. Ono H, Kondo H, Gotoda T, et al. Endoscopic mucosal resection for treatment of early gastric cancer. Gut. 2001;48(2):225-229. doi:10.1136/gut.48.2.225
  42. Bombardier C, Laine L, Reicin A, et al. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. N Engl J Med. 2000;343(21):1520-1528. doi:10.1056/nejm200011233432103
  43. Köster C, Klingelhöfer D, Groneberg DA, Schwarzer M. Rotavirus–global research density equalizing mapping and gender analysis. Vaccine. 2016;34(1):90-100. doi:10.1016/j.vaccine.2015.11.002
  44. Jia H. China’s citations catching up. Nature Index website. https://www.natureindex.com/news-blog/chinas-citations-catching-up.  Accessed October 2019. Published November 2017.
  45. OECD. Economic Surveys, China, March 2015 Overview. http://www.oecd.org/economy/surveys/China-2015-overview.pdf.   Published 2015.
  46. Boeing H. Epidemiological research in stomach cancer: progress over the last ten years. J Cancer Res Clin Oncol. 1991;117(2):133-143. doi:10.1007/BF01613137
  47. Inoue M, Tsugane S. Epidemiology of gastric cancer in Japan. Postgrad Med J. 2005;81(957):419-424. doi:10.1136/pgmj.2004.029330
  48. Adams J. Collaborations: the fourth age of research. Nature. 2013;497(7451):557-560. doi:10.1038/497557a
  49. Adams J. Collaborations: the rise of research networks. Nature. 2012;490(7420):335-336. doi:10.1038/490335a
  50. Wang L, Jacob J, Li Z. Exploring the spatial dimensions of nanotechnology development in China: the effects of funding and spillovers. Reg Stud. 2019;53(2):245-260. doi:10.1080/00343404.2018.1457216
  51. Nolte I. The future of African studies: what we can do to keep Africa at the heart of our research. J Afr Cult Stud. 2019;31(3):296-313. doi:10.1080/13696815.2019.1584552
  52. Katz JS, Martin BR. What is research collaboration? Res Policy. 1997;26(1):1-18. doi:10.1016/S0048-7333(96)00917-1
  53. Lee S, Bozeman B. The impact of research collaboration on scientific productivity. Soc Stud Sci. 2005;35(5):673-702. doi:10.1177/0306312705052359
  54. He ZL, Geng XS, Campbell-Hunt C. Research collaboration and research output: a longitudinal study of 65 biomedical scientists in a New Zealand university. Res Policy. 2009;38(2):306-317. doi:10.1016/j.respol.2008.11.011
International Journal of Health Policy and Management
Volume 10, Issue 3
March 2021
Pages 118-128

  • Received Date 28 June 2019
  • Revised Date 18 February 2020
  • Accepted Date 19 February 2020
  • First Published Date 01 March 2021
  • Published Date 01 March 2021