Document Type : Original Article
Health Intervention and Technology Assessment Program (HITAP), Ministry of Public Health, Nonthaburi, Thailand
Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore
Asc Academics, Groningen, The Netherlands
World Health Organization (WHO), Genève, Switzerland
The World Health Organization (WHO) has developed the Total System Effectiveness (TSE) framework to assist national policy-makers in prioritizing vaccines. The pilot was launched in Thailand to explore the potential use of TSE in a country with established governance structures and accountable decision-making processes for immunization policy. While the existing literature informs vaccine adoption decisions in GAVI-eligible countries, this study attempts to address a gap in the literature by examining the policy process of a non-GAVI eligible country.
A rotavirus vaccine (RVV) test case was used to compare the decision criteria made by the existing processes (Expanded Program on Immunization [EPI], and National List of Essential Medicines [NLEM]) for vaccine prioritization and the TSE-pilot model, using Thailand specific data.
The existing decision-making processes in Thailand and TSE were found to offer similar recommendations on the selection of a RVV product.
The authors believe that TSE can provide a well-reasoned and step by step approach for countries, especially low- and middle-income countries (LMICs), to develop a systematic and transparent decision-making process for immunization policy.
Supplementary file 1 contains Tables S1-S3 and Supplementary file 2 shows the detailed methodology for estimating the vaccine performance based on decision criteria.