Impact of China’s National Volume-Based Drug Procurement: A Multilevel Interrupted Time Series Analysis on Medical Expenditures in Hypertensive Patients

Document Type : Original Article

Authors

1 Institute of Integrated Traditional Chinese and Western Medicine, and Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, Chengdu, China

2 NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu, China

3 Sichuan Center of Technology Innovation for Real World Data, Chengdu, China

4 Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, China

5 Tianjin Health Care Big Data Ltd, Tianjin, China

6 Department of epidemiology and Biostatistics, West China School of Public Health, Sichuan University, Chengdu, China

Abstract

Background 
The National Volume-Based Procurement (NVBP), implemented in China in 2019, aims to reduce patients’ economic burden by lowering drug prices and promoting the use of NVBP drugs in public hospitals. We evaluated the impact of NVBP on medical expenditures among hypertensive patients, analyzing both the overall impact and variations in policy effects across individual hospitals.
 
Methods 
Using medical records from 1.17 million hypertensive patients across 82 hospitals in Tianjin (2017-2021), we conducted an interrupted time series analysis to assess expenditure changes among hypertensive patients for the treatment of hypertension, dyslipidaemia, type 2 diabetes, and chronic ischemic heart disease (IHD). Multilevel model was employed to estimate the overall impact and hospital-specific variations in policy effects.
 
Results 
NVBP implementation significantly reduced per-visit outpatient expenditures among hypertensive patients for the treatment of hypertension (-15.61%), dyslipidaemia  (-25.77%), and diabetes (-17.59%) by lowering drug expenditures. Although drug expenditures for chronic IHD decreased, non-drug expenditures increased, leading to no significant change in total expenditures for chronic IHD (-8.97%). For inpatient expenditures, no significant changes in total per-admission expenditures were observed for chronic IHD or diabetes hospitalizations. Drug expenditures for diabetes decreased significantly, but diagnostic expenditures increased, while no significant change was found in chronic IHD drug expenditures. At the individual hospital level, significant variations in policy effects were observed. Despite the overall decrease in outpatient expenditures for the treatment of hypertension, dyslipidaemia, and diabetes, only 45.6%, 67.2%, and 46.3% of hospitals, respectively, showed significant decreases, while the remainder exhibited either nonsignificant changes or increases.
 
Conclusion 
NVBP effectively reduced outpatient expenditures among hypertensive patients for the treatment of hypertension, dyslipidaemia, and diabetes, suggesting its potential to alleviate patients’ economic burdens. However, the increases in non-drug expenditures and substantial variations in policy effects across hospitals highlight a room for further improvement in policy implementation and overall effectiveness.

Keywords



Articles in Press, Accepted Manuscript
Available Online from 07 April 2025
  • Receive Date: 16 April 2024
  • Revise Date: 11 March 2025
  • Accept Date: 05 April 2025
  • First Publish Date: 07 April 2025